Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica
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چکیده
منابع مشابه
Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica.
The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ester, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalca...
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A novel triterpene, 2alpha,3beta,20,23-tetrahydroxyurs-28-oic acid (1), was isolated from the aerial part of Centella asiatica. Its structure was elucidated by spectroscopic methods, including 2D-NMR spectra. It displayed no activity against Hela and A549 cell lines at concentrations of 10 and 30 microg/mL, respectively.
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Several reviews have examined various aspects of C. asiatica including the chemistry, pharmacology, and clinical uses but none of these reviews use the systematic review approach to locate and condense all the findings. The aim of this study was to systematically review the chemical constituents of C. asiatica. Electronic databases were searched for studies examining the chemical constituents o...
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Methods The stability of CAST was monitored throughout the study using reversed phase high performance liquid chromatography. CAST or placebo capsules were administered to 33 DN subjects, in a randomized double-blind, placebocontrolled study. The dose of CAST was escalated from 60 mg to 240 mg/day over the first 12 weeks, followed by a stable dose of 240 mg/day for the remaining 40 weeks. The p...
متن کاملExtraction of Bioactive Components from Centella Asiatica Using Subcritical Water
Centella asiatica is a tropical medicinal plant with a long history of therapeutic uses, dermal disorders, venous insufficiency and microangiopathy. The substances of therapeutic interest are the saponin-containing triterpene acids and their sugar esters. Two bioactive components, asiatic acid and asiaticoside, were extracted from Centella asiatica using subcritical water as an extraction solve...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2005
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.28.173